| http://purl.uniprot.org/citations/10903763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10903763 | http://www.w3.org/2000/01/rdf-schema#comment | "CXC chemokine receptor 3 (CXCR3), predominately expressed on memory/activated T lymphocytes, is a receptor for both IFN-gamma-inducible protein-10 (gamma IP-10) and monokine induced by IFN-gamma (Mig). We report a novel finding that CXCR3 is also expressed on eosinophils. gamma IP-10 and Mig induce eosinophil chemotaxis via CXCR3, as documented by the fact that anti-CXCR3 mAb blocks gamma IP-10- and Mig-induced eosinophil chemotaxis. gamma IP-10- and Mig-induced eosinophil chemotaxis are up- and down-regulated by IL-2 and IL-10, respectively. Correspondingly, CXCR3 protein and mRNA expressions in eosinophils are up- and down-regulated by IL-2 and IL-10, respectively, as detected using flow cytometry, immunocytochemical assay, and a real-time quantitative RT-PCR technique. gamma IP-10 and Mig act eosinophils to induce chemotaxis via the cAMP-dependent protein kinase A signaling pathways. The fact that gamma IP-10 and Mig induce an increase in intracellular calcium in eosinophils confirms that CXCR3 exists on eosinophils. Besides induction to chemotaxis, gamma IP-10 and Mig also activate eosinophils to eosinophil cationic protein release. These results indicate that CXCR3-gamma IP-10 and -Mig receptor-ligand pairs as well as the effects of IL-2 and IL-10 on them may be especially important in the cytokine/chemokine environment for the pathophysiologic events of allergic inflammation, including initiation, progression, and termination in the processes."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.3.1548"xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Quan S."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Jing C."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Hansen J.B."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Poulsen L.K."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Skov P.S."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Jinquan T."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Dissing S."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Jacobi H.H."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Malling H.J."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Reimert C.M."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/author | "Millner A."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/pages | "1548-1556"xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/title | "CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma."xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://purl.uniprot.org/core/volume | "165"xsd:string |
| http://purl.uniprot.org/citations/10903763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10903763 |
| http://purl.uniprot.org/citations/10903763 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10903763 |
| http://purl.uniprot.org/uniprot/P49682#attribution-0F9D0C1636E701E16595ABB8C0537A7E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10903763 |
| http://purl.uniprot.org/uniprot/Q07325#attribution-0F9D0C1636E701E16595ABB8C0537A7E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10903763 |
| http://purl.uniprot.org/uniprot/P02778#attribution-0F9D0C1636E701E16595ABB8C0537A7E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10903763 |