| http://purl.uniprot.org/citations/10906333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10906333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10906333 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a splice variant encoding only the extracellular ligand-binding domain of the gamma-aminobutyric acid B (GABA(B)) receptor subunit GABA(B(1a)). This isoform, which we have named GABA(B(1e)), is detected in both rats and humans. While GABA(B(1e)) is a minor component of the total pool of GABA(B(1)) transcripts detected in the central nervous system, it is the primary isoform found in all peripheral tissues examined. When expressed in a heterologous system, the truncated receptor is both secreted and membrane associated. However, GABA(B(1e)) lacks the ability to bind the radiolabeled antagonist [(3)H]CGP 54626A, activate G-protein coupled inwardly rectifying potassium channels, or inhibit forskolin-induced cAMP production when it is expressed alone or together with GABA(B(2)). Interestingly, when co-expressed with GABA(B(2)), not only does the truncated receptor heterodimerize with GABA(B(2)), the association is of sufficient avidity to disrupt the normal GABA(B(1a))/GABA(B(2)) association. Despite this strong interaction, GABA(B(1e)) fails to disrupt G-protein coupled inwardly rectifying potassium activation by the full-length heterodimer pair of GABA(B(1a))/GABA(B(2))."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m005333200"xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m005333200"xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Barry G."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Barry G."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Maki R.A."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Maki R.A."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Conlon P.J."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Conlon P.J."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Eliasof S.D."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Eliasof S.D."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Petroski R.E."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Petroski R.E."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Schwarz D.A."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/author | "Schwarz D.A."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/pages | "32174-32181"xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/pages | "32174-32181"xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/title | "Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor."xsd:string |
| http://purl.uniprot.org/citations/10906333 | http://purl.uniprot.org/core/title | "Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor."xsd:string |