| http://purl.uniprot.org/citations/10913114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10913114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10913114 | http://www.w3.org/2000/01/rdf-schema#comment | "The yeast two-hybrid system was used to identify binding partners of NuMA, a component of the nuclear matrix in interphase cells. By using the C-terminal half of NuMA as bait, a human cDNA sequence coding for a 223-amino acid protein with a non-helical N-terminal domain and a C-terminal alpha-helical portion was identified and fully sequenced. It was identical to GAS41, a sequence amplified in human gliomas. The sequence of the homologous Drosophila protein was established, and the alignment for GAS41 from nine different species showed that GAS41 is a general eukaryotic protein found in species as diverse as Arabidopsis, Drosophila, Caenorhabditis elegans, yeast, and man. Northern blot analysis showed a single transcript in eight human tissues. A polyclonal antibody to GAS41 showed a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. A GFP-GAS41 fusion protein displayed equivalent patterns. In vitro GAS41 bound to the C-terminal part of the rod region of NuMA, as shown by dot overlay and by surface plasmon resonance measurements. The K(d) of the complex was 2 x 10(-)(7) m. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors found as fusion proteins in some acute leukemias. The NuMA/GAS41 interaction may provide a link between nuclear structure and gene expression."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m000994200"xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m000994200"xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/author | "Weber K."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/author | "Weber K."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/author | "Osborn M."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/author | "Osborn M."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/author | "Harborth J."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/author | "Harborth J."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/pages | "31979-31985"xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/pages | "31979-31985"xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/title | "GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/title | "GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA."xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10913114 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10913114 |
| http://purl.uniprot.org/citations/10913114 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10913114 |
| http://purl.uniprot.org/citations/10913114 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10913114 |
| http://purl.uniprot.org/citations/10913114 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10913114 |