| http://purl.uniprot.org/citations/10913159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10913159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10913159 | http://www.w3.org/2000/01/rdf-schema#comment | "We identified a developmentally regulated gene from mouse kidney whose expression is up-regulated in metanephrogenic mesenchyme cells when they are induced to differentiate to epithelial cells during kidney organogenesis. The deduced 70.5-kDa protein, originally named METS-1 (mesenchyme-to-epithelium transition protein with SH3 domains), has since been cloned as a CD2-associated protein (CD2AP). CD2AP is strongly expressed in glomerular podocytes, and the absence of CD2AP in mice results in congenital nephrotic syndrome. We have found that METS-1/CD2AP (hereafter referred to as CD2AP) is expressed at lower levels in renal tubular epithelial cells in the adult kidney, particularly in distal nephron segments. Independent yeast two-hybrid screens using the COOH-terminal region of either CD2AP or polycystin-2 as bait identified the COOH termini of polycystin-2 and CD2AP, respectively, as strong interacting partners. This interaction was confirmed in cultured cells by co-immunoprecipitation of endogenous polycystin-2 with endogenous CD2AP and vice versa. CD2AP shows a diffuse reticular cytoplasmic and perinuclear pattern of distribution, similar to polycystin-2, in cultured cells, and the two proteins co-localize by indirect double immunofluorescence microscopy. CD2AP is an adapter molecule that associates with a variety of membrane proteins to organize the cytoskeleton around a polarized site. Such a function fits well with that hypothesized for the polycystin proteins in renal tubular epithelial cells, and the present findings suggest that CD2AP has a role in polycystin-2 function."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m006624200"xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m006624200"xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Geng L."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Geng L."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Lehtonen S."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Lehtonen S."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Somlo S."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Somlo S."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Olkkonen V.M."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Olkkonen V.M."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Ora A."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Ora A."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Lehtonen E."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/author | "Lehtonen E."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/pages | "32888-32893"xsd:string |
| http://purl.uniprot.org/citations/10913159 | http://purl.uniprot.org/core/pages | "32888-32893"xsd:string |