| http://purl.uniprot.org/citations/10918580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10918580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10918580 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of the monocyte-chemoattractant-protein-1 (MCP-1) is closely linked with a non-tumorigenic phenotype in somatic cell hybrids made between the human papillomavirus type 18 (HPV 18) positive cervical carcinoma cell line HeLa and normal human fibroblasts. In contrast, MCP-1 transcription is absent in tumorigenic segregants derived from the same hybrids or in parental HeLa cells. Selectivity of MCP-1 transcription, which is regulated at the level of initiation of transcription, is mainly based on differences in the location and extension of DNAse I-hypersensitive regions (DHSR) at both ends of the gene. While TNF-alpha only moderately increases the sensitivity of pre-existing 5'-DHSRs, a 3'-end DHSR became strongly induced exclusively in non-malignant hybrids. DNA sequencing showed that the 3'-DHSR coincides with an additional AP-1 site located approximately 600 bp downstream of the polyadenylation site. Analyses of AP-1 composition revealed that MCP-1 is only expressed in those cells where jun-family members were mainly heterodimerized with the fos-related protein fra-1. In contrast, in tumorigenic cells the 1: 1 ratio between jun and fra-1 is disturbed and the MCP-1 gene is no longer expressed. Hence, alterations in the heterodimerization pattern of AP-1 and its selective accessibility to opened chromatin may represent a novel regulatory pathway in the regulation of chemokines in malignant and non-malignant HPV-positive cells."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203643"xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203643"xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Delius H."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Delius H."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Poustka A."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Poustka A."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "zur Hausen H."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "zur Hausen H."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Coy J.F."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Coy J.F."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Finzer P."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Finzer P."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Patzelt A."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Patzelt A."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Roesl F."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Roesl F."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Soto U."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/author | "Soto U."xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10918580 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |