| http://purl.uniprot.org/citations/10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10918585 | http://www.w3.org/2000/01/rdf-schema#comment | "The signal transducer and activator of transcription (STAT) proteins have been implicated in cytokine-regulated proliferation, differentiation and cell survival. Granulocyte colony-stimulating factor (G-CSF), a regulator of granulocytic differentiation, induces a robust and sustained activation of STAT3. Here, we show that introduction of dominant negative (DN) forms of STAT3 interferes with G-CSF-induced differentiation and survival in murine 32D cells. G-CSF induces expression of the cyclin-dependent kinase (cdk) inhibitor p27(KiP1) (but not p21(CiP1)), which is completely blocked by DN-STAT3. The ability of tyrosine-to-phenylalanine substitution mutants of the G-CSF receptor to activate STAT3 strongly correlated with their capacity to induce p27 expression and their ability to mediate differentiation and survival, suggesting a causal relationship between STAT3 activation, p27 expression and the observed cellular responses. We identified a putative STAT binding site in the promoter region of p27 that showed both STAT3 binding in electrophoretic mobility shift assays and functional activity in luciferase reporter assays. Finally, we studied G-CSF-induced responses in primary bone marrow and spleen cells of p27-deficient mice. Compared with wild-type, myeloid progenitors from p27-deficient mice showed significantly increased proliferation and reduced differentiation in response to G-CSF. These findings indicate that STAT3 controls myeloid differentiation, at least partly, via upregulation of p27(Kip1)."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203627"xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "van Leeuwen D."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "Ward A.C."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "Lowenberg B."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "Schelen A.M."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "Touw I.P."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "de Koning J.P."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "Soede-Bobok A.A."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/author | "Antonissen C."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/pages | "3290-3298"xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/title | "STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)."xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10918585 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10918585 |
| http://purl.uniprot.org/citations/10918585 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10918585 |
| http://purl.uniprot.org/uniprot/#_B7ZC18-mappedCitation-10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918585 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918585 |
| http://purl.uniprot.org/uniprot/#_P09919-mappedCitation-10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918585 |
| http://purl.uniprot.org/uniprot/#_P51692-mappedCitation-10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918585 |
| http://purl.uniprot.org/uniprot/#_Q3ULI4-mappedCitation-10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918585 |
| http://purl.uniprot.org/uniprot/#_O60674-mappedCitation-10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918585 |
| http://purl.uniprot.org/uniprot/#_Q3U6S9-mappedCitation-10918585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10918585 |