| http://purl.uniprot.org/citations/10922362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10922362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10922362 | http://www.w3.org/2000/01/rdf-schema#comment | "Hyperhomocysteinemia, a risk factor for vascular disease, injures endothelial cells through undefined mechanisms. We previously identified several homocysteine-responsive genes in cultured human vascular endothelial cells, including the endoplasmic reticulum (ER)-resident molecular chaperone GRP78/BiP. Here, we demonstrate that homocysteine induces the ER stress response and leads to the expression of a novel protein, Herp, containing a ubiquitin-like domain at the N terminus. mRNA expression of Herp was strongly up-regulated by inducers of ER stress, including mercaptoethanol, tunicamycin, A23187, and thapsigargin. The ER stress-dependent induction of Herp was also observed at the protein level. Immunochemical analyses using Herp-specific antibodies indicated that Herp is a 54-kDa, membrane-associated ER protein. Herp is the first integral membrane protein regulated by the ER stress response pathway. Both the N and C termini face the cytoplasmic side of the ER; this membrane topology makes it unlikely that Herp acts as a molecular chaperone for proteins in the ER, in contrast to GRP78 and other ER stress-responsive proteins. Herp may, therefore, play an unknown role in the cellular survival response to stress."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m002063200"xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m002063200"xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Miyata T."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Miyata T."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Kokame K."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Kokame K."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Agarwala K.L."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/author | "Agarwala K.L."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/pages | "32846-32853"xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/pages | "32846-32853"xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/title | "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/title | "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10922362 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10922362 |
| http://purl.uniprot.org/citations/10922362 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10922362 |