| http://purl.uniprot.org/citations/10924106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10924106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10924106 | http://www.w3.org/2000/01/rdf-schema#comment | "Barrier-to-autointegration factor (BAF) is a host cell protein that plays a crucial role in retroviral integration. Preintegration complexes (PICs) stripped of BAF lose their normal integration activity, which can be restored by incubation with purified BAF. BAF bridges double-stranded DNA both intra- and intermolecularly in a non-sequence-specific manner, leading to the formation of a nucleoprotein network. BAF also binds to the nuclear protein lamina-associated polypeptide 2 (LAP2), and is localized with chromatin during interphase and mitosis. The crystal structure of homodimeric human BAF has been determined to 1.9 A resolution. The fold of the BAF monomer resembles that of the second domain of RuvA. This comparison revealed the presence of the helix-hairpin-helix (HhH) nonspecific DNA binding motif within BAF. A novel feature of BAF's HhH motif is the occupation of the metal binding site by the epsilon-amino group of Lys 6, providing an alternative means of sequestering positive charge. Mutational analysis corroborates the HhH motif's prominent role in DNA binding and argues against a previously proposed helix-turn-helix (HTH) binding site located in another region of the monomer. A model of BAF bridging DNA via the HhH motif is proposed."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi000572w"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi000572w"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Davies D.R."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Davies D.R."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Umland T.C."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Umland T.C."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Craigie R."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Craigie R."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Wei S.-Q."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/author | "Wei S.-Q."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/pages | "9130-9138"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/pages | "9130-9138"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/title | "Structural basis of DNA bridging by barrier-to-autointegration factor."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/title | "Structural basis of DNA bridging by barrier-to-autointegration factor."xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/10924106 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10924106 |
| http://purl.uniprot.org/citations/10924106 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10924106 |