| http://purl.uniprot.org/citations/10925302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10925302 | http://www.w3.org/2000/01/rdf-schema#comment | "Galectin-3 is a beta-galactoside-binding protein implicated in diverse biological processes. We found that galectin-3 induced human monocyte migration in vitro in a dose-dependent manner, and it was chemotactic at high concentrations (1.0 microM) but chemokinetic at low concentrations (10-100 nM). Galectin-3-induced monocyte migration was inhibited by its specific mAb and was blocked by lactose and a C-terminal domain fragment of the protein, indicating that both the N-terminal and C-terminal domains of galectin-3 are involved in this activity. Pertussis toxin (PTX) almost completely blocked monocyte migration induced by high concentrations of galectin-3. Galectin-3 caused a Ca2+ influx in monocytes at high, but not low, concentrations, and both lactose and PTX inhibited this response. There was no cross-desensitization between galectin-3 and any of the monocyte-reactive chemokines examined, including monocyte chemotactic protein-1, macrophage inflammatory protein-1alpha, and stromal cell-derived factor-1alpha. Cultured human macrophages and alveolar macrophages also migrated toward galectin-3, but not monocyte chemotactic protein-1. Finally, galectin-3 was found to cause monocyte accumulation in vivo in mouse air pouches. These results indicate that galectin-3 is a novel chemoattractant for monocytes and macrophages and suggest that the effect is mediated at least in part through a PTX-sensitive (G protein-coupled) pathway."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.4.2156"xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Yamanaka T."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Sano H."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Hirashima M."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Liu F.T."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Apgar J.R."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Hsu D.K."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/author | "Kuwabara I."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/pages | "2156-2164"xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/title | "Human galectin-3 is a novel chemoattractant for monocytes and macrophages."xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://purl.uniprot.org/core/volume | "165"xsd:string |
| http://purl.uniprot.org/citations/10925302 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10925302 |
| http://purl.uniprot.org/citations/10925302 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10925302 |
| http://purl.uniprot.org/uniprot/P10147#attribution-3C82ADFE299EFD0291F9BC9BE4A2F1D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10925302 |
| http://purl.uniprot.org/uniprot/P13500#attribution-C2A92D5C5C6E392076C627FBABE0041B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10925302 |
| http://purl.uniprot.org/uniprot/P17931#attribution-C2A92D5C5C6E392076C627FBABE0041B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10925302 |
| http://purl.uniprot.org/uniprot/P48061#attribution-3C82ADFE299EFD0291F9BC9BE4A2F1D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10925302 |