| http://purl.uniprot.org/citations/10926756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10926756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10926756 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulated emigration of blood-borne leukocytes plays a defining role in lymphoid organ development, immune surveillance, and inflammatory responses. We report here that mice deficient in the homeobox gene Nkx2-3, expressed in developing visceral mesoderm, show a complex intestinal malabsorption phenotype and striking abnormalities of gut-associated lymphoid tissue and spleen suggestive of deranged leukocyte homing. Mutant Peyer's patches were reduced in number and size, intestinal villi contained few IgA(+) plasma cells, and mutant spleens were small and often atrophic, showing fused periarterial lymphoid sheaths, partially merged T and B cell zones, an absent marginal zone, and a dearth of macrophages in red pulp. Semiquantitative RT-PCR analysis and immunohistochemistry revealed down-regulation of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in endothelial cells in which Nkx2-3 is normally expressed. MAdCAM-1 is a member of the immunoglobulin superfamily, acting as an endothelial cell ligand for leukocyte homing receptors L-selectin and alpha4beta7 integrin. Our data suggest a role for a homeodomain factor in establishing the developmental and positional cues in endothelia that regulate leukocyte homing through local control of cellular adhesion and identify MAdCAM-1 as a candidate target gene of Nkx2-3."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.2000.9749"xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.2000.9749"xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Davidson N.O."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Davidson N.O."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Biben C."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Biben C."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Harvey R.P."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Harvey R.P."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Koentgen F."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Koentgen F."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Robb L."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Robb L."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Wang C.-C."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Wang C.-C."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Nassir F."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Nassir F."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Barnett L."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Barnett L."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Tarlinton D."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/author | "Tarlinton D."xsd:string |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10926756 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |