| http://purl.uniprot.org/citations/10930463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10930463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10930463 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor (TGF)-betas are secreted in large latent complexes consisting of TGF-beta, its N-terminal latency-associated peptide (LAP) propeptide, and latent TGF-beta binding protein (LTBP). LTBPs are required for secretion and subsequent deposition of TGF-beta into the extracellular matrix. TGF-beta1 associates with the 3(rd) 8-Cys repeat of LTBP-1 by LAP. All LTBPs, as well as fibrillins, contain multiple 8-Cys repeats. We analyzed the abilities of fibrillins and LTBPs to bind latent TGF-beta by their 8-Cys repeats. 8-Cys repeat was found to interact with TGF-beta1*LAP by direct cysteine bridging. LTBP-1 and LTBP-3 bound efficiently all TGF-beta isoforms, LTBP-4 had a much weaker binding capacity, whereas LTBP-2 as well as fibrillins -1 and -2 were negative. A short, specific TGF-beta binding motif was identified in the TGF-beta binding 8-Cys repeats. Deletion of this motif in the 3(rd) 8-Cys repeat of LTBP-1 resulted in loss of TGF-beta*LAP binding ability, while its inclusion in non-TGF-beta binding 3(rd) 8-Cys repeat of LTBP-2 resulted in TGF-beta binding. Molecular modeling of the 8-Cys repeats revealed a hydrophobic interaction surface and lack of three stabilizing hydrogen bonds introduced by the TGF-beta binding motif necessary for the formation of the TGF-beta*LAP - 8-Cys repeat complex inside the cells."xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.11.8.2691"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.11.8.2691"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/author | "Saharinen J."xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/author | "Saharinen J."xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/author | "Keski-Oja J."xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/author | "Keski-Oja J."xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/pages | "2691-2704"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/pages | "2691-2704"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/title | "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta."xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/title | "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta."xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10930463 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10930463 |
| http://purl.uniprot.org/citations/10930463 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10930463 |
| http://purl.uniprot.org/citations/10930463 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10930463 |
| http://purl.uniprot.org/citations/10930463 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10930463 |
| http://purl.uniprot.org/uniprot/Q14766 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10930463 |
| http://purl.uniprot.org/uniprot/Q9NS15 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10930463 |