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| http://purl.uniprot.org/citations/10931486 | http://www.w3.org/2000/01/rdf-schema#comment | "In the adult mouse tongue, an average of 11% of the gustatory receptor cells are replaced each day. In investigating homeostatic cell death mechanisms in gustatory renewing epithelium, we observed that taste receptor cells were selectively immunopositive for the bcl-2 family death factor, Bax, and for the protease Caspase-2 (Nedd2/Ich1). We determined that 8-10% of the taste receptor cells of the vallate papilla were Bax positive and that 11% were Caspase-2 positive. Some of these immunopositive taste cells had apoptotic morphological defects. Within the subset of vallate taste cells immunopositive for either Caspase-2 or Bax, up to 79% coexpressed both death factors. Bax and Caspase-2 first appeared in occasional vallate taste receptor cells on the same postnatal day-the day after birth. bax null mutation markedly reduced gustatory Caspase-2 immunoexpression. These observations suggest that taste cell death pathways utilize p53, Bax, and Caspase-2 to dispose of aged receptor cells. Apart from reducing Caspase-2 expression, Bax deficiency also altered taste organ development. bax(-/-) mice had a more profusely innervated vallate papilla, which grew to be 25% longer and taller, with the mean taste bud containing more than twice the normal number of taste cells. This augmentation of taste organ development with increased innervation is complementary to the well-documented reduction in taste organ development with sparse innervation. We propose that additional taste neurons survived programmed cell death in Bax-deficient mice, thereby providing an inductive boost to vallate gustatory development."xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.org/dc/terms/identifier | "doi:10.1002/1096-9861(20000904)424:4<640::aid-cne6>3.0.co;2-n"xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/author | "Kwan A."xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/author | "Zeng Q."xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/author | "Oakley B."xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/pages | "640-650"xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/title | "Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells."xsd:string |
| http://purl.uniprot.org/citations/10931486 | http://purl.uniprot.org/core/volume | "424"xsd:string |
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