| http://purl.uniprot.org/citations/10932180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10932180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10932180 | http://www.w3.org/2000/01/rdf-schema#comment | "The Notch-signalling pathway is important in establishing metameric pattern during somitogenesis. In mice, the lack of either of two molecules involved in the Notch-signalling pathway, Mesp2 or presenilin-1 (Ps1), results in contrasting phenotypes: caudalized versus rostralized vertebra. Here we adopt a genetic approach to analyse the molecular mechanism underlying the establishment of rostro-caudal polarity in somites. By focusing on the fact that expression of a Notch ligand, Dll1, is important for prefiguring somite identity, we found that Mesp2 initiates establishment of rostro-caudal polarity by controlling two Notch-signalling pathways. Initially, Mesp2 activates a Ps1-independent Notch-signalling cascade to suppress Dll1 expression and specify the rostral half of the somite. Ps1-mediated Notch-signalling is required to induce Dll1 expression in the caudal half of the somite. Therefore, Mesp2- and Ps1-dependent activation of Notch-signalling pathways might differentially regulate Dll1 expression, resulting in the establishment of the rostro-caudal polarity of somites."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.org/dc/terms/identifier | "doi:10.1038/78062"xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.org/dc/terms/identifier | "doi:10.1038/78062"xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Saga Y."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Saga Y."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Koizumi K."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Koizumi K."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Kitajima S."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Kitajima S."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Takagi A."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/author | "Takagi A."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/pages | "390-396"xsd:string |
| http://purl.uniprot.org/citations/10932180 | http://purl.uniprot.org/core/pages | "390-396"xsd:string |