| http://purl.uniprot.org/citations/10938268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10938268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10938268 | http://www.w3.org/2000/01/rdf-schema#comment | "omega-Conotoxins selective for N-type calcium channels are useful in the management of severe pain. In an attempt to expand the therapeutic potential of this class, four new omega-conotoxins (CVIA-D) have been discovered in the venom of the piscivorous cone snail, Conus catus, using assay-guided fractionation and gene cloning. Compared with other omega-conotoxins, CVID has a novel loop 4 sequence and the highest selectivity for N-type over P/Q-type calcium channels in radioligand binding assays. CVIA-D also inhibited contractions of electrically stimulated rat vas deferens. In electrophysiological studies, omega-conotoxins CVID and MVIIA had similar potencies to inhibit current through central (alpha(1B-d)) and peripheral (alpha(1B-b)) splice variants of the rat N-type calcium channels when coexpressed with rat beta(3) in Xenopus oocytes. However, the potency of CVID and MVIIA increased when alpha(1B-d) and alpha(1B-b) were expressed in the absence of rat beta(3), an effect most pronounced for CVID at alpha(1B-d) (up to 540-fold) and least pronounced for MVIIA at alpha(1B-d) (3-fold). The novel selectivity of CVID may have therapeutic implications. (1)H NMR studies reveal that CVID possesses a combination of unique structural features, including two hydrogen bonds that stabilize loop 2 and place loop 2 proximal to loop 4, creating a globular surface that is rigid and well defined."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m002252200"xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m002252200"xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Adams D.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Adams D.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Alewood P.F."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Alewood P.F."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Jones A."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Jones A."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Lewis R.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Lewis R.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Craik D.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Craik D.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Nielsen K.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Nielsen K.J."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Bond T."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Bond T."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Adams D.A."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Adams D.A."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Andrews P.R."xsd:string |
| http://purl.uniprot.org/citations/10938268 | http://purl.uniprot.org/core/author | "Andrews P.R."xsd:string |