| http://purl.uniprot.org/citations/10938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10938298 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we used sensory neuron specific (SNS) sodium channel gene knockout (-/-) mice to ask whether SNS sodium channel produces the slow Na(+) current ("slow") in large (>40 microm diam) cutaneous afferent dorsal root ganglion (DRG) neurons. SNS wild-type (+/+) mice were used as controls. Retrograde Fluoro-Gold labeling permitted the definitive identification of cutaneous afferent neurons. Prepulse inactivation was used to separate the fast and slow Na(+) currents. Fifty-two percent of the large cutaneous afferent neurons isolated from SNS (+/+) mice expressed only fast-inactivating Na(+) currents ("fast"), and 48% expressed both fast and slow Na(+) currents. The fast and slow current densities were 0.90 +/- 0.12 and 0.39 +/-0.16 nA/pF, respectively. Fast Na(+) currents were blocked completely by 300 nM tetrodotoxin (TTX), while slow Na(+) currents were resistant to 300 nM TTX, confirming that the slow Na(+) currents observed in large cutaneous DRG neurons are TTX-resistant (TTX-R). Slow Na(+) currents could not be detected in large cutaneous afferent neurons from SNS (-/-) mice; these cells expressed only fast Na(+) current, and it was blocked by 300 nM TTX. The fast Na(+) current density in SNS (-/-) neurons was 1.47 +/-0. 14 nA/pF, approximately 60% higher than the current density observed in SNS (+/+) mice (P < 0.02). A low-voltage-activated TTX-R Na(+) current ("persistent") observed in small C-type neurons is not present in large cutaneous afferent neurons from either SNS (+/+) or SNS (-/-) mice. These results show that the slow TTX-R Na(+) current in large cutaneous afferent DRG is produced by the SNS sodium channel."xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.org/dc/terms/identifier | "doi:10.1152/jn.2000.84.2.710"xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/author | "Cummins T.R."xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/author | "Waxman S.G."xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/author | "Renganathan M."xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/author | "Hormuzdiar W.N."xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/name | "J Neurophysiol"xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/pages | "710-718"xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/title | "alpha-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons."xsd:string |
| http://purl.uniprot.org/citations/10938298 | http://purl.uniprot.org/core/volume | "84"xsd:string |
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