| http://purl.uniprot.org/citations/10939588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10939588 | http://www.w3.org/2000/01/rdf-schema#comment | "Microdissection and differential display PCR were used to identify genes preferentially expressed in the highly proliferative terminal end buds (TEBs) in the mammary gland of 45-day-old virgin rats. One clone exhibited 87% homology to the human p190-B gene encoding a novel Rho-Gap. Using in situ hybridization, p190-B was detected in both the TEBs and the terminal ducts, with the highest expression observed in the outer layer of TEBs. During normal mammary gland development, p190-B mRNA expression was highest in the virgin mammary gland and decreased during late pregnancy and lactation. Interestingly, increased levels of p190-B mRNA relative to the normal mammary gland were seen in a subset of murine mammary tumors that appeared to be less well differentiated and potentially more aggressive. Transient transfection of a p190-B expression construct into MCF-10A human mammary epithelial cells resulted in disruption of the actin cytoskeleton, which suggests a role for p190-B in regulating the signaling pathways that influence cell migration and invasion. These results suggest that p190-B may be required for virgin mammary gland development, and its aberrant expression may occur in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/author | "Roy D."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/author | "Contreras A."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/author | "Gonzales M."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/author | "Gay J."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/author | "Rosen J.M."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/author | "Chakravarty G."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/name | "Cell Growth Differ"xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/pages | "343-354"xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/title | "P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer."xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10939588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10939588 |
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| http://purl.uniprot.org/uniprot/Q6TUE6#attribution-45A92BF8B0E958461686B9DD04529CC0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10939588 |
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| http://purl.uniprot.org/uniprot/#_Q6TUE6-mappedCitation-10939588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10939588 |
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