| http://purl.uniprot.org/citations/10944117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10944117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10944117 | http://www.w3.org/2000/01/rdf-schema#comment | "We present evidence that both corepressors SMRT and N-CoR exist in large protein complexes with estimated sizes of 1.5-2 MDa in HeLa nuclear extracts. Using a combination of conventional and immunoaffinity chromatography, we have successfully isolated a SMRT complex and identified histone deacetylase 3 (HDAC3) and transducin (beta)-like I (TBL1), a WD-40 repeat-containing protein, as the subunits of the purified SMRT complex. We show that the HDAC3-containing SMRT and N-CoR complexes can bind to unliganded thyroid hormone receptors (TRs) in vitro. We demonstrate further that in Xenopus oocytes, both SMRT and N-CoR also associate with HDAC3 in large protein complexes and that injection of antibodies against HDAC3 or SMRT/N-CoR led to a partial relief of repression by unliganded TR/RXR. These findings thus establish both SMRT and N-CoR complexes as bona fide HDAC-containing complexes and shed new light on the molecular pathways by which N-CoR and SMRT function in transcriptional repression."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.16.4342"xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.16.4342"xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Wong J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Wong J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Nawaz Z."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Nawaz Z."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Liu J.M."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/author | "Liu J.M."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/pages | "4342-4350"xsd:string |
| http://purl.uniprot.org/citations/10944117 | http://purl.uniprot.org/core/pages | "4342-4350"xsd:string |