| http://purl.uniprot.org/citations/10946286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10946286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10946286 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokines play important roles in leukocyte trafficking as well as function regulation. In this study, we described the identification and characterization of a novel CXC chemokine from a human dendritic cell (DC) cDNA library, the full-length cDNA of which contains an open reading frame encoding 111 aa with a putative signal peptide of 34 aa. This CXC chemokine shares greatest homology with macrophage inflammatory protein (MIP)-2alphabeta, hence is designated as MIP-2gamma. Mouse MIP-2gamma was identified by electrocloning and is highly homologous to human MIP-2gamma. Northern blotting revealed that MIP-2gamma was constitutively and widely expressed in most normal tissues with the greatest expression in kidney, but undetectable in most tumor cell lines except THP-1 cells. In situ hybridization analysis demonstrated that MIP-2gamma was mainly expressed by the epithelium of tubules in the kidney and hepatocytes in the liver. Although no detectable expression was observed in freshly isolated or PMA-treated monocytes, RT-PCR analysis revealed MIP-2gamma expression by monocyte-derived DC. Recombinant MIP-2gamma from 293 cells is about 9.5 kDa in size and specifically detectable by its polyclonal Ab developed by the immunization with its 6His-tagged fusion protein. The eukaryotically expressed MIP-2gamma is a potent chemoattractant for neutrophils, and weaker for DC, but inactive to monocytes, NK cells, and T and B lymphocytes. Receptor binding assays showed that MIP-2gamma does not bind to CXCR2. This implies that DC might contribute to the innate immunity through the production of neutrophil-attracting chemokines and extends the knowledge about the regulation of DC migration."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.5.2588"xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.5.2588"xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Yuan Z."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Yuan Z."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Wan T."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/author | "Wan T."xsd:string |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10946286 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |