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http://purl.uniprot.org/citations/10947884http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10947884http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

The purpose of the study was to test whether the pentanucleotide insertion/deletion polymorphism in the 3'-untranslated region (3'-UTR) of the leptin receptor gene, which has previously been associated with serum insulin levels in obese subjects, is associated with insulin levels and the risk of type 2 diabetes in non-diabetic middle-aged men.

Subjects and design

We studied these associations in a prospective population-based nested case-control study in 41 men who developed type 2 diabetes during 4-year follow-up and 81 controls who were matched for age, obesity, baseline glucose and insulin and other strongest risk factors. Both the cases and the controls came from a cohort of 985 men who had no diabetes at baseline.

Results

There was one homozygote and 22 heterozygotes for the 3'-UTR insertion allele amongst all 122 men. The carrier frequency of this allele was 9.8% amongst the cases and 23.5% amongst the controls. At baseline, the mean fasting serum insulin was 12.2 mU L-1 in the 23 men who were heterozygous or homozygous for the insertion allele and 17.1 mU L-1 in the 99 men who were homozygous for the deletion allele (P = 0.005). In a logistic regression model adjusting for four strongest non-matched predictors of type 2 diabetes, the carriers of the insertion allele had a 79% reduced risk of diabetes (OR = 0.21; 95% CI = 0.06-0.77, P = 0.019), compared with non-carriers.

Conclusion

Our findings support the hypothesis that alterations in the leptin signalling system could contribute to serum insulin levels and the development of type 2 diabetes."xsd:string
http://purl.uniprot.org/citations/10947884http://purl.org/dc/terms/identifier"doi:10.1046/j.1365-2796.2000.00696.x"xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/author"Kontula K."xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/author"Salonen J.T."xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/author"Oksanen L."xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/author"Tuomainen T.P."xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/author"Lakka H.M."xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/name"J Intern Med"xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/pages"77-83"xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/title"The common pentanucleotide polymorphism of the 3'-untranslated region of the leptin receptor gene is associated with serum insulin levels and the risk of type 2 diabetes in non-diabetic men: a prospective case-control study."xsd:string
http://purl.uniprot.org/citations/10947884http://purl.uniprot.org/core/volume"248"xsd:string
http://purl.uniprot.org/citations/10947884http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10947884
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