| http://purl.uniprot.org/citations/10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10954610 | http://www.w3.org/2000/01/rdf-schema#comment | "Exposure of Schizosaccharomyces pombe cells to UV light results in increased uvi15(+) gene expression at both the mRNA and protein levels, leading to elevated cell survival. This UV-induced expression of the uvi15(+) gene was reduced in Deltasty1 and Deltawis1 cells lacking the stress-activated protein kinase pathway, but not in DNA damage checkpoint mutants. To further understand the cellular mechanisms responsible for this UV-induced expression, the transcription rate and mRNA half-life were investigated. Transcription run-on assays revealed that the rate of uvi15(+) transcription was increased 1.8-fold regardless of Sty1 when cells were UV irradiated. The half-life of uvi15(+) mRNA was also increased 1.5-fold after UV irradiation, but it was decreased in the Deltasty1 background for both basal and UV-induced mRNAs, indicating that the stress-activated MAPK cascade can mediate UV-induced gene expression by increasing mRNA half-life. Deletion analyses identified a 54 nt element downstream of the distal poly(A) site, which was involved in the increased half-life of uvi15(+) mRNA. These results suggest that both Sty1 and the 3'-regulatory element regulate UV-induced expression of the uvi15(+) gene at the post-transcriptional level."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/28.17.3392"xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Lee W."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Park S.D."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Kim J.B."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Jang Y.K."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Seong R.H."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/author | "Choe S.Y."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/pages | "3392-3402"xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/title | "The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level."xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/10954610 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10954610 |
| http://purl.uniprot.org/citations/10954610 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10954610 |
| http://purl.uniprot.org/uniprot/#_P52890-mappedCitation-10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10954610 |
| http://purl.uniprot.org/uniprot/#_P78955-mappedCitation-10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10954610 |
| http://purl.uniprot.org/uniprot/#_P26306-mappedCitation-10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10954610 |
| http://purl.uniprot.org/uniprot/#_Q02099-mappedCitation-10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10954610 |
| http://purl.uniprot.org/uniprot/#_P33886-mappedCitation-10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10954610 |
| http://purl.uniprot.org/uniprot/#_P50531-mappedCitation-10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10954610 |
| http://purl.uniprot.org/uniprot/#_Q01663-mappedCitation-10954610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10954610 |