| http://purl.uniprot.org/citations/10958683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958683 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated a cDNA, frl (formin-related gene in leukocytes), a novel mammalian member of the formin gene family. The frl cDNA encodes a 160-kDa protein, FRL, that possesses FH1, FH2, and FH3 domains that are well conserved among other Formin-related proteins. An FRL protein is mainly localized in the cytosol and is highly expressed in spleen, lymph node, and bone marrow cells. Formin-related genes and proteins have been reported to play crucial roles in morphogenesis, cell polarity, and cytokinesis through interaction with Rho family small GTPases. FRL binds to Rac at its N-terminal region including the FH3 domain and associates with profilin at the FH1 domain. In a macrophage cell line, P388D1, overexpression of a truncated form of FRL containing only the FH3 domain (FH3-FRL) strongly inhibited cell adhesion to fibronectin and migration upon stimulation with a chemokine. Moreover, expression of the truncated FH3-FRL protein resulted in apoptotic cell death of P388D1 cells, suggesting that the truncated FH3-FRL protein may interfere with signals of FRL. Overexpression in the P388D1 cells of full-length FRL or of the truncated protein containing the FH3 and FH1 domains, with simultaneous expression of the truncated FH3-FRL protein, blocked apoptotic cell death and inhibition of cell adhesion and migration. These results suggest that FRL may play a role in the control of reorganization of the actin cytoskeleton in association with Rac and also in the regulation of the signal for cell survival."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.18.6872-6881.2000"xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.18.6872-6881.2000"xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/author | "Taniuchi I."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/author | "Taniuchi I."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/author | "Yayoshi-Yamamoto S."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/author | "Yayoshi-Yamamoto S."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/pages | "6872-6881"xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/pages | "6872-6881"xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/title | "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/title | "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages."xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10958683 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10958683 |
| http://purl.uniprot.org/citations/10958683 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10958683 |
| http://purl.uniprot.org/citations/10958683 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10958683 |
| http://purl.uniprot.org/citations/10958683 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10958683 |