| http://purl.uniprot.org/citations/10958785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958785 | http://www.w3.org/2000/01/rdf-schema#comment | "Contact-mediated axon repulsion by ephrins raises an unresolved question: these cell surface ligands form a high-affinity multivalent complex with their receptors present on axons, yet rather than being bound, axons can be rapidly repelled. We show here that ephrin-A2 forms a stable complex with the metalloprotease Kuzbanian, involving interactions outside the cleavage region and the protease domain. Eph receptor binding triggered ephrin-A2 cleavage in a localized reaction specific to the cognate ligand. A cleavage-inhibiting mutation in ephrin-A2 delayed axon withdrawal. These studies reveal mechanisms for protease recognition and control of cell surface proteins, and, for ephrin-A2, they may provide a means for efficient axon detachment and termination of signaling."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.289.5483.1360"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.289.5483.1360"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/author | "Flanagan J.G."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/author | "Flanagan J.G."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/author | "Osterfield M."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/author | "Osterfield M."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/pages | "1360-1365"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/pages | "1360-1365"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/title | "Regulated cleavage of a contact-mediated axon repellent."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/title | "Regulated cleavage of a contact-mediated axon repellent."xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/10958785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10958785 |
| http://purl.uniprot.org/citations/10958785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10958785 |
| http://purl.uniprot.org/citations/10958785 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10958785 |
| http://purl.uniprot.org/citations/10958785 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10958785 |