| http://purl.uniprot.org/citations/10958791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958791 | http://www.w3.org/2000/01/rdf-schema#comment | "Four members of the glial cell line-derived neurotrophic factor family have been identified (GDNF, neurturin, persephin, and enovin/artemin). They bind to a specific membrane-anchored GDNF family receptor as follows: GFRalpha-1 for GDNF, GFRalpha-2 for neurturin, GFRalpha-3 for enovin/artemin, and (chicken) GFRalpha-4 for persephin. Subsequent signaling occurs through activation of a common transmembrane tyrosine kinase, cRET. GFRalpha-4, the coreceptor for persephin, was previously identified in chicken only. We describe the cloning and characterization of a mammalian persephin receptor GFRalpha-4. The novel GFRalpha receptor is substantially different in sequence from all known GFRalphas, including chicken GFRalpha-4, and lacks the first cysteine-rich domain present in all previously characterized GFRalphas. At least two different GFRalpha-4 splice variants exist in rat tissues, differing at their respective COOH termini. GFRalpha-4 mRNA is expressed at low levels in different brain areas in the adult as well as in some peripheral tissues including testis and heart. Recombinant rat GFRalpha-4 variants were expressed in mammalian cells and shown to be at least partially secreted from the cells. Persephin binds specifically and with high affinity (K(D) = 6 nm) to the rat GFRalpha-4 receptor, but no cRET activation could be demonstrated. Although the newly characterized mammalian GFRalpha-4 receptor is structurally divergent from previously characterized GFRalpha family members, we suggest that it is a mammalian orthologue of the chicken persephin receptor. This discovery will allow a more detailed investigation of the biological targets of persephin action and its potential involvement in diseases of the nervous system."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m003867200"xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m003867200"xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Gordon R.D."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Gordon R.D."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Scott R."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Scott R."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Verhasselt P."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Verhasselt P."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Hoefnagel E."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Hoefnagel E."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Masure S."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Masure S."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Ibanez C.F."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Ibanez C.F."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Cik M."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Cik M."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Lesage A.S.J."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Lesage A.S.J."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Nosrat C.A."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Nosrat C.A."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Van Gompel P."xsd:string |
| http://purl.uniprot.org/citations/10958791 | http://purl.uniprot.org/core/author | "Van Gompel P."xsd:string |