| http://purl.uniprot.org/citations/10958805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958805 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanism(s) by which impaired mitochondrial respiratory function and the accumulation of lipid droplets and mitochondria in hearts of copper-deficient rats occur remains unclear. It is not known whether specific components of the regulatory pathway involved in mitochondrial biogenesis, such as mitochondrial transcription factor A (mtTFA) and nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2), are activated in copper deficiency. Little is known about gene expression of enzymes involved in fatty acid oxidation (FAO) in hearts of copper-deficient rats. Male weanling rats were fed copper-adequate (CuA), copper-deficient (CuD) or pair-fed (CuP) diets for 5 wk. Mitochondria and lipid droplet volume densities from electron micrographs were greater and there was an elevation in the mtTFA protein level in hearts of copper-deficient rats. DNA binding activities of NRF-1 and NRF-2 did not differ among the groups. Northern blot analysis of cardiac tissue revealed that transcripts of F(1)F(0)-ATP synthase subunit c were greater, but mRNA levels of ATP synthase beta subunit and the FAO enzyme, medium-chain acyl-CoA dehydrogenase (MCAD), were lower in hearts of copper-deficient rats. Long-chain acyl-CoA dehydrogenase (LCAD) mRNA levels did not differ among treatment groups. These results suggest that certain components of the mitochondrial biogenesis program are activated in hearts of copper-deficient rats. F(1)F(0)-ATP synthase beta subunit and MCAD transcript levels remain low, which may contribute to impaired mitochondrial respiratory function, decreased fatty acid utilization and lipid droplet accumulation in hearts of copper-deficient rats."xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.org/dc/terms/identifier | "doi:10.1093/jn/130.9.2143"xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/author | "Kelly D.P."xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/author | "Mao S."xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/author | "Leone T.C."xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/author | "Medeiros D.M."xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/name | "J Nutr"xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/pages | "2143-2150"xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/title | "Mitochondrial transcription factor A is increased but expression of ATP synthase beta subunit and medium-chain acyl-CoA dehydrogenase genes are decreased in hearts of copper-deficient rats."xsd:string |
| http://purl.uniprot.org/citations/10958805 | http://purl.uniprot.org/core/volume | "130"xsd:string |
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