| http://purl.uniprot.org/citations/10958845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10958845 | http://www.w3.org/2000/01/rdf-schema#comment | "In order to investigate the evolution of conotoxin multigene families among two closely related vermivorous CONUS: species, we sequenced 104 four-loop conotoxin mRNAs from two individuals of CONUS: ebraeus and compared these with sequences already obtained from CONUS: abbreviatus. In contrast to the diversity of conotoxin sequences obtained from C. abbreviatus, only two common sequence variants were recovered from C. ebraeus. Segregation patterns of the variants in these two individuals and restriction digests of four-loop conotoxin amplification products from nine additional individuals suggest that the common variants are alleles from a single locus. These two putative alleles differ at nine positions that occur nonrandomly in the toxin-coding region of the sequences. Moreover, all substitutions are at nonsynonymous sites and are responsible for seven amino acid differences among the predicted amino acid sequences of the alleles. These results imply that conotoxin diversity is driven by strong diversifying selection and some form of frequency-dependent or overdominant selection at conotoxin loci, and they suggest that diverse conotoxin multigene families can originate from duplications at polymorphic loci. Furthermore, none of the sequences recovered from C. ebraeus appeared to be orthologs of loci from C. abbreviatus, and attempts to amplify orthologous sequences with locus-specific primers were unsuccessful among these species. These patterns suggest that venoms of closely related CONUS: species may differ due to the differential expression of conotoxin loci."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.molbev.a026412"xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.molbev.a026412"xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/author | "Duda T.F. Jr."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/author | "Duda T.F. Jr."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/author | "Palumbi S.R."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/author | "Palumbi S.R."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/author | "Duda T.F. Jr"xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/name | "Mol. Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/name | "Mol. Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/pages | "1286-1293"xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/pages | "1286-1293"xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/title | "Evolutionary diversification of multigene families: allelic selection of toxins in predatory cone snails."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/title | "Evolutionary diversification of multigene families: allelic selection of toxins in predatory cone snails."xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/10958845 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10958845 |
| http://purl.uniprot.org/citations/10958845 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10958845 |
| http://purl.uniprot.org/citations/10958845 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10958845 |
| http://purl.uniprot.org/citations/10958845 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10958845 |
| http://purl.uniprot.org/uniprot/Q9NCT5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10958845 |