| http://purl.uniprot.org/citations/10970095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10970095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10970095 | http://www.w3.org/2000/01/rdf-schema#comment | "X-linked lymphoproliferative (XLP) disease is a fatal immunological disorder that renders the immune system unable to respond effectively to Epstein-Barr virus (EBV) infection. The gene that encodes a protein termed SAP or SH2D1A is either deleted or mutated in XLP patients, resulting in uncontrolled B- and T-cell proliferation upon EBV infection. Here, we report the cloning and characterization of the mouse SAP gene. It is localized on the mouse X chromosome and comprises four exons spanning approximately 25 kb. Its expression appears to be restricted to T lymphocytes. Whereas a high level of SAP expression is observed in Thl cells, only small amounts are detectable in Th2 cells. Moreover, SAP expression is down-regulated upon in vitro activation of T cells, including CD4+, CD8+ single-positive T cells, and Thl and Th2 cells. This study provides valuable information for in-depth genetic and biochemical analysis of the function of SAP in the immune system."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.org/dc/terms/identifier | "doi:10.1007/s002510000215"xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.org/dc/terms/identifier | "doi:10.1007/s002510000215"xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Coyle A."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Coyle A."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Sayos J."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Sayos J."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Howie D."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/author | "Howie D."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/pages | "805-815"xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/pages | "805-815"xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/title | "Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease."xsd:string |
| http://purl.uniprot.org/citations/10970095 | http://purl.uniprot.org/core/title | "Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease."xsd:string |