| http://purl.uniprot.org/citations/10970857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10970857 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(-/-) background. CD45 suppresses the tumorigenic potential of the kinase by dephosphorylation of the Tyr394 autophosphorylation site. In CD45(-/-) thymocytes the kinase is switched to a hyperactive oncogenic state, resulting in increased resistance to apoptosis. Transformation occurs in early CD4(-)CD8(-) thymocytes during the process of TCR-beta chain rearrangement by a recombinase-independent mechanism. Our findings represent the first example in which a tyrosine phosphatase in situ prevents the oncogenic actions of a SRC: family tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.17.4644"xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Higgins D."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Turner M."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Baker M."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Gamble J."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Coleman N."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "O'Brien P.C."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Alexander D.R."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Pingel S."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Tooze R."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/author | "Yang F.T."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/pages | "4644-4654"xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/title | "Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice."xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10970857 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10970857 |
| http://purl.uniprot.org/citations/10970857 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10970857 |
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| http://purl.uniprot.org/uniprot/#_Q05C79-mappedCitation-10970857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10970857 |