http://purl.uniprot.org/citations/10970861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10970861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10970861 | http://www.w3.org/2000/01/rdf-schema#comment | "A new isoform of the human estrogen receptor-alpha (hER-alpha) has been identified and characterized. This 46 kDa isoform (hERalpha46) lacks the N-terminal 173 amino acids present in the previously characterized 66 kDa isoform (hERalpha66). hERalpha46 is encoded by a new class of hER-alpha transcript that lacks the first coding exon (exon 1A) of the ER-alpha gene. We demonstrated that these Delta1A hER-alpha transcripts originate from the E and F hER-alpha promoters and are produced by the splicing of exon 1E directly to exon 2. Functional analysis of hERalpha46 showed that, in a cell context sensitive to the transactivation function AF-2, this receptor is an effective ligand-inducible transcription factor. In contrast, hERalpha46 is a powerful inhibitor of hERalpha66 in a cell context where the transactivating function of AF-1 predominates over AF-2. The mechanisms by which the AF-1 dominant-negative action is exerted may involve heterodimeri zation of the two receptor isoforms and/or direct competition for the ER-alpha DNA-binding site. hERalpha66/hERalpha46 ratios change with the cell growth status of the breast carcinoma cell line MCF7, suggesting a role of hERalpha46 in cellular proliferation."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.17.4688"xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.17.4688"xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Reid G."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Reid G."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Gannon F."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Gannon F."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Kos M."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Kos M."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Brand H."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Brand H."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Denger S."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Denger S."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Flouriot G."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Flouriot G."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Metivier R."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Metivier R."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Sonntag-Buck V."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/author | "Sonntag-Buck V."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
http://purl.uniprot.org/citations/10970861 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |