| http://purl.uniprot.org/citations/10975519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10975519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10975519 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide range of eukaryotes and has been shown to be required for proper chromosome transmission in Tetrahymena. Here we report that Ipl1/aurora kinase and its genetically interacting phosphatase, Glc7/PP1, are responsible for the balance of H3 phosphorylation during mitosis in Saccharomyces cerevisiae and Caenorhabditis elegans. In these models, both enzymes are required for H3 phosphorylation and chromosome segregation, although a causal link between the two processes has not been demonstrated. Deregulation of human aurora kinases has been implicated in oncogenesis as a consequence of chromosome missegregation. Our findings reveal an enzyme system that regulates chromosome dynamics and controls histone phosphorylation that is conserved among diverse eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00034-9"xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00034-9"xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Hunt D.F."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Hunt D.F."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Smith M.M."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Smith M.M."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Allis C.D."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Allis C.D."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Sun Z.-W."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Sun Z.-W."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Bishop D.K."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Bishop D.K."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Brame C.J."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Brame C.J."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Caldwell J.A."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Caldwell J.A."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Grushcow J.M."xsd:string |
| http://purl.uniprot.org/citations/10975519 | http://purl.uniprot.org/core/author | "Grushcow J.M."xsd:string |