http://purl.uniprot.org/citations/10981960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10981960 | http://www.w3.org/2000/01/rdf-schema#comment | "The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebral meninges and specific downregulation of Tek/Tie-2, the receptor for angiopoietin-1. We also show that dysmegakaryopoiesis in Fli-1 null embryos resembles that frequently seen in patients with terminal deletions of 11q (Jacobsen or Paris-Trousseau Syndrome). We map the megakaryocytic defects in 14 Jacobsen patients to a minimal region on 11q that includes the Fli-1 gene and suggest that dysmegakaryopoiesis in these patients may be caused by hemizygous loss of Fli-1."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(00)00017-0"xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Jones C."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Bernstein A."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Tunnacliffe A."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Favier R."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Chien K."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Hart A."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Grossfeld P."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/author | "Melet F."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/pages | "167-177"xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/title | "Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia."xsd:string |
http://purl.uniprot.org/citations/10981960 | http://purl.uniprot.org/core/volume | "13"xsd:string |
http://purl.uniprot.org/citations/10981960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10981960 |
http://purl.uniprot.org/citations/10981960 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10981960 |
http://purl.uniprot.org/uniprot/P26323#attribution-C7C61710690AE07944BB3881EE039567 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10981960 |
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http://purl.uniprot.org/uniprot/#_A0A0R4J0A4-mappedCitation-10981960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10981960 |
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http://purl.uniprot.org/uniprot/#_A0A494BA23-mappedCitation-10981960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10981960 |