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http://purl.uniprot.org/citations/10981960http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10981960http://www.w3.org/2000/01/rdf-schema#comment"The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebral meninges and specific downregulation of Tek/Tie-2, the receptor for angiopoietin-1. We also show that dysmegakaryopoiesis in Fli-1 null embryos resembles that frequently seen in patients with terminal deletions of 11q (Jacobsen or Paris-Trousseau Syndrome). We map the megakaryocytic defects in 14 Jacobsen patients to a minimal region on 11q that includes the Fli-1 gene and suggest that dysmegakaryopoiesis in these patients may be caused by hemizygous loss of Fli-1."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)00017-0"xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Jones C."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Bernstein A."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Tunnacliffe A."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Favier R."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Chien K."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Hart A."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Grossfeld P."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/author"Melet F."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/pages"167-177"xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/title"Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia."xsd:string
http://purl.uniprot.org/citations/10981960http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/10981960http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10981960
http://purl.uniprot.org/citations/10981960http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10981960
http://purl.uniprot.org/uniprot/P26323#attribution-C7C61710690AE07944BB3881EE039567http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10981960
http://purl.uniprot.org/uniprot/#_A0A0G2JDM6-mappedCitation-10981960http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10981960
http://purl.uniprot.org/uniprot/#_A0A1B0GQW9-mappedCitation-10981960http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10981960
http://purl.uniprot.org/uniprot/#_E9Q7U5-mappedCitation-10981960http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10981960
http://purl.uniprot.org/uniprot/#_A0A0R4J0A4-mappedCitation-10981960http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10981960
http://purl.uniprot.org/uniprot/#_A2A9D4-mappedCitation-10981960http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10981960
http://purl.uniprot.org/uniprot/#_A0A494BA23-mappedCitation-10981960http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10981960