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http://purl.uniprot.org/citations/10981966http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10981966http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10981966http://www.w3.org/2000/01/rdf-schema#comment"The OX2 membrane glycoprotein (CD200) is expressed on a broad range of tissues including lymphoid cells, neurons, and endothelium. We report the characterization of an OX2 receptor (OX2R) that is a novel protein restricted to cells of the myeloid lineage. OX2 and its receptor are both cell surface glycoproteins containing two immunoglobulin-like domains and interact with a dissociation constant of 2.5 microM and koff 0.8 s(-1), typical of many leukocyte protein membrane interactions. Pervanandate treatment of macrophages showed that OX2R could be phosphorylated on tyrosine residues. Blockade of the OX2-OX2R interaction with an OX2R mAb exacerbated the disease model experimental allergic encephalomyelitis. These data, together with data from an OX2-deficient mouse (R. M. Hoek et al., submitted), suggest that myeloid function can be controlled in a tissue-specific manner by the OX2-OX2R interaction."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)00023-6"xsd:string
http://purl.uniprot.org/citations/10981966http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)00023-6"xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Wright G.J."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Wright G.J."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Willis A.C."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Willis A.C."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Hoek R.M."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Hoek R.M."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Barclay A.N."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Barclay A.N."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Brown M.H."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Brown M.H."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Puklavec M.J."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Puklavec M.J."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Sedgwick J.D."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/author"Sedgwick J.D."xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/pages"233-242"xsd:string
http://purl.uniprot.org/citations/10981966http://purl.uniprot.org/core/pages"233-242"xsd:string