| http://purl.uniprot.org/citations/10984530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10984530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10984530 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we describe the identification and characterization of a nuclear body (matrix-associated deacetylase body) whose formation and integrity depend on deacetylase activity. Typically, there are 20-40 0.5-microM bodies per nucleus, although the size and number can vary substantially. The structure appears to contain both class I and the recently described class II histone deacetylases (HDAC)5 and 7 along with the nuclear receptor corepressors SMRT (silencing mediator for retinoid and thyroid receptor) and N-CoR (nuclear receptor corepressor). Addition of the deacetylase inhibitors trichostatin A and sodium butyrate completely disrupt these nuclear bodies, providing a demonstration that the integrity of a nuclear body is enzyme dependent. We demonstrate that HDAC5 and 7 can associate with at least 12 distinct proteins, including several members of the NuRD and Sin3A repression complexes, and appear to define a new but related complex."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.97.19.10330"xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.97.19.10330"xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Downes M."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Downes M."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Kao H.-Y."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Kao H.-Y."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Ordentlich P."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Ordentlich P."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Alvarez J.G.A."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/author | "Alvarez J.G.A."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/pages | "10330-10335"xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/pages | "10330-10335"xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/title | "Identification of a nuclear domain with deacetylase activity."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/title | "Identification of a nuclear domain with deacetylase activity."xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/10984530 | http://purl.uniprot.org/core/volume | "97"xsd:string |