| http://purl.uniprot.org/citations/10987270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10987270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10987270 | http://www.w3.org/2000/01/rdf-schema#comment | "The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner. To investigate whether mutations of this enzyme occur in hepatocellular carcinoma (HCC), KAP mRNA was analyzed by reverse transcription-PCR (RT-PCR), followed by cloning and sequencing. Eight of 14 biopsy tissues obtained from advanced HCC, 6 of 13 surgically removed HCC tissues, and 2 of the adjacent noncancerous tissues contained aberrant KAP transcripts. Using the yeast two-hybrid system, five of seven representative KAP mutants were shown to be defective in interacting with Cdk2. These data suggest a possible role of KAP mutations in multiple-step hepatocarcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Yeh C.-T."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Yeh C.-T."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Chen T.-C."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Chen T.-C."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Liaw Y.-F."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Liaw Y.-F."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Lu S.-C."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Lu S.-C."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Peng C.-Y."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/author | "Peng C.-Y."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/pages | "4697-4700"xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/pages | "4697-4700"xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/title | "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/title | "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/10987270 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10987270 |
| http://purl.uniprot.org/citations/10987270 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10987270 |