| http://purl.uniprot.org/citations/11001880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11001880 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of CCR6 (chemokine receptor 6) expression during B-cell ontogeny and antigen-driven B-cell differentiation was analyzed. None of the CD34(+)Lin(-) hematopoietic stem cell progenitors or the CD34(+)CD19(+) (pro-B) or the CD19(+)CD10(+) (pre-B/immature B cells) B-cell progenitors expressed CCR6. CCR6 is acquired when CD10 is lost and B-cell progeny matures, entering into the surface immunoglobulin D(+) (sIgD(+)) mature B-cell pool. CCR6 is expressed by all bone marrow-, umbilical cord blood-, and peripheral blood-derived naive and/or memory B cells but is absent from germinal center (GC) B cells of secondary lymphoid organs. CCR6 is down-regulated after B-cell antigen receptor triggering and remains absent during differentiation into immunoglobulin-secreting plasma cells, whereas it is reacquired at the stage of post-GC memory B cells. Thus, within the B-cell compartment, CCR6 expression is restricted to functionally mature cells capable of responding to antigen challenge. In transmigration chemotactic assays, macrophage inflammatory protein (MIP)-3alpha/CC chemokine ligand 20 (CCL20) induced vigorous migration of B cells with differential chemotactic preference toward sIgD(-) memory B cells. These data suggest that restricted patterns of CCR6 expression and MIP-3alpha/CCL20 responsiveness are integral parts of the process of B-lineage maturation and antigen-driven B-cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/author | "Bernard J."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/author | "Louache F."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/author | "Foussat A."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/author | "Galanaud P."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/author | "Richard Y."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/author | "Krzysiek R."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/author | "Lefevre E.A."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/pages | "2338-2345"xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/title | "Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells."xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/11001880 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11001880 |
| http://purl.uniprot.org/citations/11001880 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11001880 |
| http://purl.uniprot.org/uniprot/P51684#attribution-08545403A848DA915E36CD75388BD341 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11001880 |