| http://purl.uniprot.org/citations/11004705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11004705 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipopolysaccharide (LPS) is known to bind to several receptors on macrophages, including CD14 and macrophage scavenger receptor class A types I and II (MSR-A), and stimulates macrophages to release various inflammatory mediators. MSR-A recognizes a broad range of polyanionic ligands such as chemically modified lipoproteins, LPS of Gram-negative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defence. In this study, mice lacking MSR-A were used to elucidate the role of MSR-A in endotoxin shock. Peritoneal macrophages from MSR-A-deficient (MSR-A(-/-)) mice bound less remarkably to LPS than those from wild-type (MSR-A(+/+)) mice and the binding activity of MSR-A(+/+) macrophages to LPS was reduced by the addition of an anti-MSR-A antibody. Clearance of LPS in serum was retarded in MSR-A(-/-) mice after intraperitoneal administration of LPS. LPS-induced expression of cytokines in the liver was similar in MSR-A(+/+) and MSR-A(-/-) mice, but levels of interleukin (IL)-1beta expression and serum IL-1beta were lower in MSR-A(-/-) mice. Administration of large doses of LPS resulted in a higher mortality of MSR-A(+/+) mice and pretreatment with an IL-1 receptor antagonist reduced the mortality. Thus, MSR-A-mediated macrophage activation plays a negative role in protecting mice from endotoxin shock by enhancing IL-1beta production by macrophages."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.org/dc/terms/identifier | "doi:10.1002/1096-9896(2000)9999:9999<::aid-path692>3.0.co;2-u"xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Naito M."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Abo T."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Arakawa M."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Kamata N."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Hasegawa G."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Umezu H."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/author | "Miyaji C."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/name | "J Pathol"xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/pages | "263-272"xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/title | "Role of macrophage scavenger receptor in endotoxin shock."xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/11004705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11004705 |
| http://purl.uniprot.org/citations/11004705 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11004705 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRS5-mappedCitation-11004705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11004705 |
| http://purl.uniprot.org/uniprot/#_Q3U2C3-mappedCitation-11004705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11004705 |
| http://purl.uniprot.org/uniprot/#_Q8CED7-mappedCitation-11004705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11004705 |
| http://purl.uniprot.org/uniprot/#_P30204-mappedCitation-11004705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11004705 |