| http://purl.uniprot.org/citations/11007485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11007485 | http://www.w3.org/2000/01/rdf-schema#comment | "HF-1 b, an SP1 -related transcription factor, is preferentially expressed in the cardiac conduction system and ventricular myocytes in the heart. Mice deficient for HF-1 b survive to term and exhibit normal cardiac structure and function but display sudden cardiac death and a complete penetrance of conduction system defects, including spontaneous ventricular tachycardia and a high incidence of AV block. Continuous electrocardiographic recordings clearly documented cardiac arrhythmogenesis as the cause of death. Single-cell analysis revealed an anatomic substrate for arrhythmogenesis, including a decrease and mislocalization of connexins and a marked increase in action potential heterogeneity. Two independent markers reveal defects in the formation of ventricular Purkinje fibers. These studies identify a novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00089-1"xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Chien K.R."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Kondo R."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Feld G.K."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Ruiz-Lozano P."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Wollert K.C."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Minamisawa S."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Clark R.B."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Giles W.R."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Fiset C."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Kubalak S.W."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Brown A.B."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Gourdie R.G."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Barrere-Lemaire S."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Nguyen-Tran V.T."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Norman L.W."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/author | "Rahme M.M."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/pages | "671-682"xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/title | "A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages."xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/11007485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11007485 |