| http://purl.uniprot.org/citations/11007759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11007759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11007759 | http://www.w3.org/2000/01/rdf-schema#comment | "CD5(+) B-1 cells are known to be unresponsive to B cell receptor (BCR)-mediated growth signals but instead undergo apoptosis. However, the B-1 cells from Lyn kinase-deficient (Lyn-/-) mice exhibited an enhanced proliferative response upon BCR cross-linking. It has been reported that BCR-mediated signaling in B-1 cells is negatively regulated by signals from CD22, CD5 and CD72 co-receptors, and that Lyn kinase plays a crucial role in tyrosine phosphorylation of immunoreceptor tyrosine-based inhibitory motifs on the CD22 and CD72, which recruits SHP-1 to the BCR complex. We found that Lyn kinase is also essential for the tyrosine phosphorylation of CD5 and subsequent recruitment of SHP-1 in B-1 cells upon cross-linking of BCR. Moreover, a distinct subpopulation of B-1 cells was found to express cell surface Ly49, which is known as a MHC class I-binding negative regulatory receptor on NK cells. Ly49 was rapidly tyrosine phosphorylated upon cross-linking of BCR and SHP-1 was found to recruit to the phosphorylated Ly49. Addition of F(ab')(2) fragments of anti-Ly49 antibodies partially blocked negative signals in B-1 cells. Thus two co-receptors, CD5 and Ly49, which are unique to B-1 cells, play a role in the regulation of B-1 cell activation. These results indicate that BCR-mediated signals in B-1 cells are strictly and negatively regulated through multiple pathways, that are dependent on Lyn kinase activity."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/12.10.1417"xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/12.10.1417"xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/author | "Ochi H."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/author | "Ochi H."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/name | "Int. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/name | "Int. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/pages | "1417-1423"xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/pages | "1417-1423"xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/title | "Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/title | "Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity."xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/11007759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11007759 |
| http://purl.uniprot.org/citations/11007759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11007759 |
| http://purl.uniprot.org/citations/11007759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11007759 |
| http://purl.uniprot.org/citations/11007759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11007759 |
| http://purl.uniprot.org/uniprot/P25911 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11007759 |
| http://purl.uniprot.org/uniprot/P13379 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11007759 |