Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/11007822http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11007822http://www.w3.org/2000/01/rdf-schema#comment"

Background

CD11/CD18 beta(2) integrins are involved in leukocyte adhesion to the activated endothelium, and therefore represent a possible therapeutic target in the prevention of ischaemic acute renal failure (ARF).

Methods

To assess the effect of an anti-CD11b monoclonal antibody (mAb) in ischaemic ARF, uninephrectomized Fischer rats were subjected to 45 or 60 min of warm renal ischaemia, then received 1 mg of anti-CD11b mAb 5 min before reperfusion.

Results

After 45 min of ischaemia, renal function tests at 24 and 48 h were less altered in mAb-treated than in control rats, but after 60 min of ischaemia the same level of renal insufficiency was observed in the two groups. In parallel, milder tubular necrosis and less leukocyte infiltration were observed in the treated group after 45 min of ischaemia, but no difference was seen after 60 min compared to the control group. The mAb was detected on blood neutrophils up to 48 h after infusion and a marked down-regulation of CD11b expression on neutrophil surfaces was documented by flow cytometry.

Conclusion

These results indicate that anti-CD11b mAb administered prior to reperfusion decreases moderate ischaemic ARF but fails to prevent renal injury secondary to prolonged ischaemia in this model."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.org/dc/terms/identifier"doi:10.1093/ndt/15.10.1556"xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Ishibashi M."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Kawashima H."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Miyasaka M."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Blanc-Brunat N."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Dubernard J.M."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Margonari J."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Martin X."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Revillard J.P."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Steghens J.P."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Tajra L.C."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/author"Vivier G."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/name"Nephrol Dial Transplant"xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/pages"1556-1561"xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/title"Antibody-induced modulation of the leukocyte CD11b integrin prevents mild but not major renal ischaemic injury."xsd:string
http://purl.uniprot.org/citations/11007822http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/11007822http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11007822
http://purl.uniprot.org/citations/11007822http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11007822
http://purl.uniprot.org/uniprot/#_A0A8I5ZTY9-mappedCitation-11007822http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11007822
http://purl.uniprot.org/uniprot/#_A0A8I5ZVL1-mappedCitation-11007822http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11007822
http://purl.uniprot.org/uniprot/#_B2RYB8-mappedCitation-11007822http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11007822
http://purl.uniprot.org/uniprot/#_Q4KLK5-mappedCitation-11007822http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11007822
▶