| http://purl.uniprot.org/citations/11007869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11007869 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the effects of G-protein beta and gamma subunit heterodimers on human alpha(1B) (N-type) Ca channels expressed in HEK293 cells. All of the known beta subunits (beta1-beta5) produced voltage-dependent inhibition of alpha(1B) Ca channels, depending on the gamma subunit found in the heterodimer. beta1-beta4 subunits inhibited Ca channels when paired with gamma1-gamma3. However, beta5 subunits only produced inhibition when paired with gamma2. In contrast, heterodimers between beta5 subunits and RGS (regulators of G-protein signaling) proteins containing GGL domains did not produce inhibition of Ca channels. However, GGL domain-containing RGS proteins (e.g., RGS6 and RGS11) did block the ability of Gbeta5/gamma2 heterodimers to inhibit Ca channels. Because all of the G-protein beta subunits are found in the nervous system, we conclude that they may all potentially participate in Ca channel inhibition. The interaction of GGL-containing RGS proteins with Gbeta5gamma2 suggests a novel way in which Ca channels can be regulated."xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.20-19-07143.2000"xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/author | "Siderovski D.P."xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/author | "Zhou J.Y."xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/author | "Miller R.J."xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/pages | "7143-7148"xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/title | "Selective regulation of N-type Ca channels by different combinations of G-protein beta/gamma subunits and RGS proteins."xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/11007869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11007869 |
| http://purl.uniprot.org/citations/11007869 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11007869 |
| http://purl.uniprot.org/uniprot/O14775#attribution-2ED6F33D9AFC6D609C94D1DE07063FA4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11007869 |