| http://purl.uniprot.org/citations/11007882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11007882 | http://www.w3.org/2000/01/rdf-schema#comment | "The G-protein-coupled metabotropic glutamate receptor subtype 7a (mGluR7a) is a member of group III metabotropic glutamate receptors that plays an important role as a presynaptic receptor in regulating transmitter release at glutamatergic synapses. Here we report that the protein interacting with C-kinase (PICK1) binds to the C terminus (ct) of mGluR7a. In the yeast two-hybrid system, the extreme ct of mGluR7a was shown to interact with the PSD-95/Discs large/ZO-1 (PDZ) domain of PICK1. Pull-down assays indicated that PICK1 was retained by a glutathione S-transferase fusion of ct-mGluR7a. Furthermore, recombinant and native PICK1/mGluR7a complexes were coimmunoprecipitated from COS-7 cells and rat brain tissue, respectively. Confocal microscopy showed that both PICK1 and mGluR7a displayed synaptic colocalization in cultured hippocampal neurons. PICK1 has previously been shown to bind protein kinase C alpha-subunit (PKCalpha), and mGluR7a is known to be phosphorylated by PKC. We show a relationship between these three proteins using recombinant PICK1, mGluR7, and PKCalpha, where they were co-immunoprecipitated as a complex from COS-7 cells. In addition, PICK1 caused a reduction in PKCalpha-evoked phosphorylation of mGluR7a in in vitro phosphorylation assays. These results suggest a role for PICK1 in modulating PKCalpha-evoked phosphorylation of mGluR7a."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.20-19-07252.2000"xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/author | "Nakajima Y."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/author | "Nakanishi S."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/author | "Henley J.M."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/author | "Kitano J."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/author | "Dev K.K."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/author | "Braithwaite S.P."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/pages | "7252-7257"xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/title | "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7."xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/11007882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11007882 |
| http://purl.uniprot.org/citations/11007882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11007882 |
| http://purl.uniprot.org/uniprot/P35400#attribution-04B88770258E7C729CBBDDD5D600159A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11007882 |
| http://purl.uniprot.org/uniprot/P35400#attribution-DA1C55C28B16709A7BB1D06198F92036 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11007882 |
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