| http://purl.uniprot.org/citations/11013217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11013217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11013217 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family, was shown to be involved in the response to various stresses in cultured cells. However, there is little in vivo evidence indicating a role for a JNK pathway in the stress response of an organism. We identified the Caenorhabditis elegans mek-1 gene, which encodes a 347 amino acid protein highly homologous to mammalian MKK7, an activator of JNK. Mek-1 reporter fusion proteins are expressed in pharyngeal muscle, uterus, a portion of intestine, and neurons. A mek-1 deletion mutant is hypersensitive to copper and cadmium ions and to starvation. A wild-type mek-1 transgene rescued the hypersensitivity to the metal ions. Double mutants of mek-1 with an eat-5, eat-11 or eat-18 mutation, which are characterized by a limited feeding defect, showed distinct growth defects under normal conditions. Expression of an activated form of MEK-1 in the whole animal or specifically in the pharynx inhibited pharyngeal pumping. These results suggest a role for mek-1 in stress responses, with a focus in the pharynx and/or intestine."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.19.5148"xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.19.5148"xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Koga M."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Koga M."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Avery L."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Avery L."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Ohshima Y."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Ohshima Y."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Zwaal R."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/author | "Zwaal R."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/pages | "5148-5156"xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/pages | "5148-5156"xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses."xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/11013217 | http://purl.uniprot.org/core/volume | "19"xsd:string |