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http://purl.uniprot.org/citations/11014643http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

In this study, the capacity of CD8+ T cells to act as a potential effector mechanism in pancreatic xenograft rejection was examined.

Methods

The fate of pancreatic islet xenografts was studied in mice deficient in MHC class II molecules and CD4+ T cells. Fetal pig pancreas (FPP) or Wistar rat islets (RI) were transplanted into nondiabetic or streptozotocin-induced diabetic I-A knock-out (CII K/O) mice.

Results

CII K/O mice were capable of rejecting both RI and FPP grafts. RI graft survival was not prolonged compared with wild type C57BL/6 controls. However, FPP grafts did survive longer in CII K/O recipients than in C57BL/J6 mice. Both RI and FPP graft rejection were CD8+ T-cell phenomena in CII K/O mice, as anti-CD8 monoclonal antibody prolonged graft survival, there were increased CD8+ T cells in the grafts and spleens of CII K/O recipients, and cell-mediated cytotoxicity was a CD8+ T-cell phenomenon associated with activation of the perforin/granzyme B system. By contrast, RI and FPP graft rejection was a CD4+ T cell-dependent phenomenon in wild type C57BL/6 mice with graft survival prolonged by anti-CD4 monoclonal antibody. There were increased numbers of CD4+ T cells, and cell-mediated cytotoxicity was a CD4+ T-cell phenomenon associated with activation of the Fas/FasL lytic pathway.

Conclusions

The results demonstrate that, in the absence of CD4+ T cells, CD8+ T cells were capable of rejecting both rat and pig pancreatic islet xenografts."xsd:string
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http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/author"Feng X."xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/author"Yi S."xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/author"Patel A."xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/author"O'Connell P.J."xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/author"Hawthorne W."xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/author"Walters S."xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/name"Transplantation"xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/pages"896-906"xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/title"CD8+ T cells are capable of rejecting pancreatic islet xenografts."xsd:string
http://purl.uniprot.org/citations/11014643http://purl.uniprot.org/core/volume"70"xsd:string
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