| http://purl.uniprot.org/citations/11021537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11021537 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-fes protooncogene encodes a nonreceptor tyrosine kinase (Fes) implicated in cytokine receptor signal transduction, neutrophil survival, and myeloid differentiation. To determine the role of Fes in embryonic development and hematopoiesis, we engineered a null mutation of the murine c-fes locus. c-fes-/-mice are viable but not born in the expected Mendelian ratios. Live born c-fes-/-mice exhibit lymphoid/myeloid homeostasis defects, compromised innate immunity, and increased Stat activation in response to GM-CSF and IL-6 signaling. Therefore, increased cytokine responsiveness in the absence of Fes leads to abnormal myeloid proliferation and functional defects in the macrophage lineage."xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(00)00039-x"xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/author | "Feldman R.A."xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/author | "Simon M.C."xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/author | "Hackenmiller R."xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/pages | "397-407"xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/title | "Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice."xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/11021537 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11021537 |
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| http://purl.uniprot.org/uniprot/P16879 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11021537 |
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