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http://purl.uniprot.org/citations/11024213http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11024213http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the polymorphism distribution of MICA gene exon 5 microsatellite in Shanghai Han population and study the relationship of MICA gene and its closely linked gene HLA B.

Methods

The microsatellite polymorphism of MICA exon 5 in 175 unrelated healthy individuals were investigated using PCR-heteroduplex analysis.

Results

(1)There are 5 alleles of the microsatellite polymorphism in exon 5 of the MICA gene in Shanghai Han population, the gene frequency of MICA*A5 is the highest(39.14%), the next is MICA*A5.1(22.29%). (2)There is strong linkage disequilibrium between the HLA-B and MICA STR loci, e.g. MICA*A5 and HLA-B15, MICA*A4 and HLA-B27.

Conclusion

The polymorphism distribution of MICA gene and the linkage disequilibrium between MICA and HLA-B have deviations in different ethnic groups."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/author"Guo Z."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/author"Ge Y."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/author"Fan L."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/author"Yang J."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/author"Xu L."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/author"Yao F."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/pages"332-335"xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/title"Study on polymorphism of MICA exon 5 microsatellite in Shanghai Han population."xsd:string
http://purl.uniprot.org/citations/11024213http://purl.uniprot.org/core/volume"17"xsd:string
http://purl.uniprot.org/citations/11024213http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11024213
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