| http://purl.uniprot.org/citations/11030344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11030344 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell cycle checkpoints lead to the inhibition of cell cycle progression following DNA damage. A cell-free system derived from Xenopus eggs has been established that reconstitutes the checkpoint pathway inhibiting DNA replication initiation. DNA containing double-strand breaks inhibits replication initiation in a dose-dependent manner. Upon checkpoint activation, a prereplicative complex is assembled that contains ORC, Cdc6, Cdc7, and MCM proteins but lacks Cdc45. The checkpoint is ATM dependent. Cdk2/CyclinE acts downstream of ATM and is downregulated by Cdk2 phosphorylation on tyrosine 15. Cdk2AF/CyclinE is refractory to checkpoint signaling, and Cdc25A overrides the checkpoint and restores DNA replication. This report provides the description of a DNA damage checkpoint pathway that prevents the onset of S phase independently of the transcriptional function of p53 in a vertebrate organism."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)00063-0"xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Gautier J."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Robertson K."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Gottesman M."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Grieco D."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Costanzo V."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Ying C.Y."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/author | "Avvedimento E."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/pages | "649-659"xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/title | "Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage."xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/11030344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11030344 |
| http://purl.uniprot.org/citations/11030344 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11030344 |
| http://purl.uniprot.org/uniprot/#_P23437-mappedCitation-11030344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11030344 |
| http://purl.uniprot.org/uniprot/P23437 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11030344 |