| http://purl.uniprot.org/citations/11030620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11030620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11030620 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a nuclear pathway that rapidly degrades unspliced pre-mRNAs in yeast. This involves 3'-->5' degradation by the exosome complex and 5'-->3' degradation by the exonuclease Rat1p. 3'-->5' degradation is normally the major pathway and is regulated in response to carbon source. Inhibition of pre-mRNA degradation resulted in increased levels of pre-mRNAs and spliced mRNAs. When splicing was inhibited by mutation of a splicing factor, inhibition of turnover resulted in 20-to 50-fold accumulation of pre-mRNAs, accompanied by increased mRNA production. Splicing of a reporter construct with a 3' splice site mutation was also increased on inhibition of turnover, showing competition between degradation and splicing. We propose that nuclear pre-mRNA turnover represents a novel step in the regulation of gene expression."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00065-9"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00065-9"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/author | "Tollervey D."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/author | "Tollervey D."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/author | "Bousquet-Antonelli C."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/author | "Bousquet-Antonelli C."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/author | "Presutti C."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/author | "Presutti C."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/pages | "765-775"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/pages | "765-775"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/title | "Identification of a regulated pathway for nuclear pre-mRNA turnover."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/title | "Identification of a regulated pathway for nuclear pre-mRNA turnover."xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/11030620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11030620 |
| http://purl.uniprot.org/citations/11030620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11030620 |
| http://purl.uniprot.org/citations/11030620 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11030620 |
| http://purl.uniprot.org/citations/11030620 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11030620 |