| http://purl.uniprot.org/citations/11032817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11032817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11032817 | http://www.w3.org/2000/01/rdf-schema#comment | "Importins are members of a family of transport receptors (karyopherins) that mediate the nucleocytoplasmic transport of protein and RNA cargoes. We identified importin-11 as a potential new human member of this family, on the basis of limited similarity to the Saccharomyces cerevisiae protein, Lph2p, and cloned the complete open reading frame. Importin-11 interacts with the Ran GTPase, and constitutively shuttles between the nuclear and cytoplasmic compartments. A yeast dihybrid screen identified UbcM2, an E2-type ubiquitin-conjugating enzyme, as a binding partner and potential transport cargo for importin-11. Importin-11 and UbcM2 interact directly, and the complex is disassembled by Ran:GTP but not by Ran:GDP. UbcM2 is constitutively nuclear and shuttles between the nuclear and cytoplasmic compartments. Nuclear import of UbcM2 requires Ran and importin-11, and is inhibited by wheatgerm agglutinin, energy depletion or dominant interfering mutants of Ran and importin-beta. These data establish importin-11 as a new member of the karyopherin family of transport receptors, and identify UbcM2 as a nuclear member of the E2 ubiquitin-conjugating enzyme family."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.20.5502"xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.20.5502"xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/author | "Plafker S.M."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/author | "Plafker S.M."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/author | "Macara I.G."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/author | "Macara I.G."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/pages | "5502-5513"xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/pages | "5502-5513"xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/title | "Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/title | "Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2."xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/11032817 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11032817 |
| http://purl.uniprot.org/citations/11032817 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11032817 |
| http://purl.uniprot.org/citations/11032817 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11032817 |
| http://purl.uniprot.org/citations/11032817 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11032817 |
| http://purl.uniprot.org/uniprot/P52483 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11032817 |
| http://purl.uniprot.org/uniprot/Q9UI26 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11032817 |