| http://purl.uniprot.org/citations/11032855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11032855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11032855 | http://www.w3.org/2000/01/rdf-schema#comment | "Sphingolipid signaling pathways have been implicated in many critical cellular events. Sphingosine-1-phosphate (SPP), a sphingolipid metabolite found in high concentrations in platelets and blood, stimulates members of the endothelial differentiation gene (Edg) family of G protein-coupled receptors and triggers diverse effects, including cell growth, survival, migration, and morphogenesis. To determine the in vivo functions of the SPP/Edg signaling pathway, we disrupted the Edg1 gene in mice. Edg1(-/-) mice exhibited embryonic hemorrhage leading to intrauterine death between E12.5 and E14.5. Vasculogenesis and angiogenesis appeared normal in the mutant embryos. However, vascular maturation was incomplete due to a deficiency of vascular smooth muscle cells/pericytes. We also show that Edg-1 mediates an SPP-induced migration response that is defective in mutant cells due to an inability to activate the small GTPase, Rac. Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci10905"xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci10905"xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Hobson J.P."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Hobson J.P."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Proia R.L."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Proia R.L."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Spiegel S."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Spiegel S."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Liu C.H."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Liu C.H."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Nava V.E."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Nava V.E."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Lee M.J."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Lee M.J."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Deng C.X."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Deng C.X."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Hla T."xsd:string |
| http://purl.uniprot.org/citations/11032855 | http://purl.uniprot.org/core/author | "Hla T."xsd:string |