| http://purl.uniprot.org/citations/11034372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11034372 | http://www.w3.org/2000/01/rdf-schema#comment | "Humans and mice with genetic deficiencies that lead to loss of signaling through common gamma-chain (gammac)-containing cytokine receptors have severe defects in B and T lymphocytes. In humans, these deficiencies lead to a complete absence of T cells, whereas in mice, small thymuses give rise to normal numbers of peripheral T cells. We have examined the first wave of developing T cells in Jak3-/-, IL-7-/-, and IL-7Ralpha-/-fetal mice, and have found a near absence of thymic progenitor cells. This deficiency is highlighted by the complete inability of Jak3-/-progenitor cells to reconstitute T cell development in the presence of competing wild-type cells. These data clearly demonstrate a strong common basis for the T cell deficiencies in mice and humans lacking gammac/Jak3 signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.7.3680"xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/author | "Berg L.J."xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/author | "Baird A.M."xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/author | "Lucas J.A."xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/pages | "3680-3688"xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/title | "A profound deficiency in thymic progenitor cells in mice lacking Jak3."xsd:string |
| http://purl.uniprot.org/citations/11034372 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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