| http://purl.uniprot.org/citations/11035033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11035033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11035033 | http://www.w3.org/2000/01/rdf-schema#comment | "The transport factor p115 is essential for endoplasmic reticulum (ER) to Golgi traffic. P115 interacts with two Golgi proteins, GM130 and giantin, suggesting that they might also participate in ER-Golgi traffic. Here, we show that peptides containing the GM130 or the giantin p115 binding domain and anti-GM130 and anti-giantin antibodies inhibit transport of vesicular stomatitis virus (VSV)-G protein to a mannosidase II-containing Golgi compartment. To determine whether p115, GM130, and giantin act together or sequentially during transport, we compared kinetics of traffic inhibition. Anti-p115, anti-GM130, and anti-giantin antibodies inhibited transport at temporally distinct steps, with the p115-requiring step before the GM130-requiring stage, and both preceding the giantin-requiring stage. Examination of the distribution of the arrested VSV-G protein showed that anti-p115 antibodies inhibited transport at the level of vesicular-tubular clusters, whereas anti-GM130 and anti-giantin antibodies inhibited after the VSV-G protein moved to the Golgi complex. Our results provide the first evidence that GM130 and giantin are required for the delivery of a cargo protein to the mannosidase II-containing Golgi compartment. These data are most consistent with a model where transport from the ER to the cis/medial-Golgi compartments requires the action of p115, GM130, and giantin in a sequential rather than coordinate mechanism."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m007957200"xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m007957200"xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Alvarez C."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Alvarez C."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Sztul E."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Sztul E."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Garcia-Mata R."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Garcia-Mata R."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Hauri H.P."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/author | "Hauri H.P."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/pages | "2693-2700"xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/pages | "2693-2700"xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/title | "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/title | "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic."xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11035033 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11035033 |
| http://purl.uniprot.org/citations/11035033 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11035033 |